Modulating the immune response and the pericardial environment with LPS or prednisolone in the axolotl does not change the regenerative capacity of cryoinjured hearts

@article{Pedersen2020ModulatingTI,
  title={Modulating the immune response and the pericardial environment with LPS or prednisolone in the axolotl does not change the regenerative capacity of cryoinjured hearts},
  author={Kathrine Pedersen and Rikke Kongsgaard Rasmussen and Anita Dittrich and Michael Pedersen and Henrik Lauridsen},
  journal={The FASEB Journal},
  year={2020},
  volume={34}
}
Humans are incapable of regenerating after suffering from a myocardial infarction. Instead a fibrotic scar without contractile or electrically conducting properties is formed. This results in cardiac remodeling, which steers the heart towards heart failure. It is hypothesized that the time frame and composition of infiltrating immune cells play a role in the fibrotic outcome.