Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration.

  title={Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration.},
  author={Usha Acharya and Shetal Patel and Edmund J Koundakjian and Kunio Nagashima and Xianlin Han and Jairaj K Acharya},
  volume={299 5613},
Mutations in proteins of the Drosophila phototransduction cascade, a prototypic guanine nucleotide-binding protein-coupled receptor signaling system, lead to retinal degeneration and have been used as models to understand human degenerative disorders. Here, modulating the sphingolipid biosynthetic pathway rescued retinal degeneration in Drosophila mutants. Targeted expression of Drosophila neutral ceramidase rescued retinal degeneration in arrestin and phospholipase C mutants. Decreasing flux… CONTINUE READING
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