Modulating role for thromboxane in the tubuloglomerular feedback response in the rat.

@article{Welch1988ModulatingRF,
  title={Modulating role for thromboxane in the tubuloglomerular feedback response in the rat.},
  author={William J. Welch and Christopher Stuart Wilcox},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={81 6},
  pages={
          1843-9
        }
}
Some studies have indicated that PGs can modulate the single nephron tubuloglomerular feedback (TGF) response. The aim of this study was to define the specific role of the vasoconstrictor PG, TX, by administration to rats of either vehicle (group 1; n = 20) or drugs that inhibit either cyclooxygenase (indomethacin [indo], 5 mg.kg-1, group 2, n = 17), TX synthetase (UK-38,485 [UK], 100 mg.kg-1, group 3, n = 19), or TX receptors (SQ-29,548 [SQ], 8 mg.kg-1, group 4, n = 14, or L-641,953 [L], 50 mg… CONTINUE READING
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