Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides.

@article{Jurk2006ModulatingRO,
  title={Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides.},
  author={Marion Jurk and Andrea Kritzler and Bettina Schulte and Sibylle Tluk and Christian Schetter and Arthur M. Krieg and Joerg Vollmer},
  journal={European journal of immunology},
  year={2006},
  volume={36 7},
  pages={1815-26}
}
Toll-like receptors (TLR) 7 and 8 are closely related members of the TLR family of pathogen-associated molecular pattern recognition receptors and have an important function in activation of innate immune responses upon viral infection. TLR7 can be activated selectively by the guanosine analogue loxoribine, whereas the imidazoquinoline derivative Resiquimod (R-848) activates both TLR7 and TLR8. We demonstrate that co-incubation of R-848 with thymidine homopolymer oligodeoxynucleotides (ODN… CONTINUE READING

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