Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs.

@article{Guidot1997ModulatingPA,
  title={Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs.},
  author={David M. Guidot and Stuart L. Bursten and Glenn C. Rice and Robert B. Chaney and Jack W Singer and A J Repine and Brooks M. Hybertson and John E. Repine},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1997},
  volume={273 5},
  pages={L957-L966}
}
  • D. Guidot, S. Bursten, +5 authors J. Repine
  • Published 1 November 1997
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
We determined that lisofylline, a potent inhibitor of oleate- and linoleate-containing phosphatidic acid formation (half-maximal inhibitory concentration = 40 nM), prevented oxidant-mediated capillary leak in isolated rat lungs given interleukin-8 (IL-8) intratracheally and perfused with human neutrophils. Lung leak was prevented by lung, but not neutrophil, lisofylline pretreatment. Furthermore, although lisofylline inhibited IL-8-stimulated neutrophil production of phosphatidic acid in vitro… Expand
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