Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability.

@article{Huang2010ModulatingOO,
  title={Modulating osteogenesis of mesenchymal stem cells by modifying growth factor availability.},
  author={Zhinong Huang and Pei-Gen Ren and T. H. Ma and Robert L. Smith and Stuart B Goodman},
  journal={Cytokine},
  year={2010},
  volume={51 3},
  pages={305-10}
}
Growth factors control the proliferation and differentiation of osteoprogenitor cells. This study explores the effects of modulating growth factors (VEGF, IGF-1, FGF-2 and BMP-2) on osteogenesis of mesenchymal stem cells (MSCs) in vitro. Constant and profiled delivery protocols, in accordance with protein expression in vitro, were applied to deliver or neutralize growth factors. Cell number, alkaline phosphatase (ALP-2) and osteocalcin (OC) expression, and mineralization were measured as… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

Similar Papers

Loading similar papers…