Modulating lipid dynamics and membrane fluidity to drive rapid folding of a transmembrane barrel

@inproceedings{Maurya2013ModulatingLD,
  title={Modulating lipid dynamics and membrane fluidity to drive rapid folding of a transmembrane barrel},
  author={Svetlana Rajkumar Maurya and Deepti Chaturvedi and Radhakrishnan Mahalakshmi},
  booktitle={Scientific reports},
  year={2013}
}
Lipid-protein interactions, critical for the folding, stability and function of membrane proteins, can be both of mechanical and chemical nature. Mechanical properties of lipid systems can be suitably influenced by physical factors so as to facilitate membrane protein folding. We demonstrate here that by modulating lipid dynamics transiently using heat, rapid folding of two 8-stranded transmembrane β-barrel proteins OmpX and OmpA(1-171), in micelles and vesicles, can be achieved within seconds… CONTINUE READING
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