Modulating influence on HIV/AIDS by interacting RANTES gene variants.

  title={Modulating influence on HIV/AIDS by interacting RANTES gene variants.},
  author={Ping Nicole An and George W. Nelson and Lihua Wang and Sharyne M. Donfield and James Jerome Goedert and John W Phair and David Vlahov and Susan P Buchbinder and William L. Farrar and William S. Modi and Stephen J. O'Brien and Cheryl A. Winkler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 15},
RANTES (regulated on activation normal T cell expressed and secreted), a ligand for the CC chemokine receptor 5, potently inhibits HIV-1 replication in vitro. We tested the influence of four RANTES single nucleotide polymorphism (SNP) variants and their haplotypes on HIV-1 infection and AIDS progression in five AIDS cohorts. Three SNPs in the RANTES gene region on chromosome 17 (403A in the promoter, In1.1C in the first intron, and 3'222C in the 3' untranslated region) are associated with… CONTINUE READING
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