Modulating effects of dietary fats on methylmercury toxicity and distribution in rats.

@article{Jin2007ModulatingEO,
  title={Modulating effects of dietary fats on methylmercury toxicity and distribution in rats.},
  author={Xiaolei Jin and Esther Lok and Genevieve Bondy and Don Caldwell and Rudi W. Mueller and Kamla Kapal and Charlotte Beatrice Armstrong and Michele Taylor and Stan Kubow and Raksha Mehta and Hing Man Chan},
  journal={Toxicology},
  year={2007},
  volume={230 1},
  pages={
          22-44
        }
}
Fish consumption is the most important source of human exposure to methylmercury (MeHg). Since fish is also a rich source of n-3 polyunsaturated fatty acids, this study was conducted to examine the effects of dietary fats on MeHg-induced acute toxicity in rats. Weanling male Sprague Dawley rats were administered semi-purified casein-based isocaloric diet containing soy oil, seal oil, docosahexaenoic acid (DHA), fish oil, or lard for 28 days. Rats were then gavaged with 0, 1, or 3 mg MeHg/kg… CONTINUE READING
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