Modulating conjunctival wound healing

  title={Modulating conjunctival wound healing},
  author={M. Francesca Cordeiro and Lydia Chang and Kin Sheng Lim and Julie T. Daniels and Robert Pleass and Dilani Siriwardena and Peng Tee Khaw},
Advances in molecular and cell biology have led to an expansion in our knowledge and understanding of the processes involved in wound healing. We review existing and potential therapies modulating the conjunctival scarring response, with particular reference to glaucoma filtration surgery. We discuss how the refinement of present antimetabolite regimens can minimise complications and improve surgical results, and advocate their use in carefully selected patient groups. Perhaps the most… 
Modulation of wound healing : clinical practice ARTICLE IN PRESS
An overview of the most important efforts that have been made to explore novel, more specific, and safer agents to prevent glaucoma filtration failure and improve surgery outcome is provided.
Development and investigation of implantable tablets for wound healing modulation after trabeculectomy
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  • Medicine, Biology
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Methods to investigate and simulate dissolution of excipientless tablets in non-sink conditions within the subconjunctival space are established.
Overview of cicatricial modulators in glaucoma fistulizing surgery
Alternative options to those most used as healing modulators, mitomycin C (MMC) and 5-fluorouracil, commonly associated with complications are researched, covering publications from 1972 to 2019.
Suramin modulates wound healing of rabbit conjunctiva after trabeculectomy: Comparison with mitomycin C
The results of the current study suggest that suramin has beneficial effects on wound healing in glaucoma surgery, and effectively prolongs bleb survival in rabbits.
Ocular surface reconstruction: recent advances and future outlook
Much progress has been made in the fields of microbiology, stem-cell research, tissue engineering, and bioartificial devices for the treatment of the heterogeneous group of ocular surface disorders.
A Novel Technique for Conjunctivoplasty in a Rabbit Model: Platelet-Rich Fibrin Membrane Grafting
This experimental study showed the beneficial effects of the PRF membrane on conjunctival healing and provides mechanical support as a scaffold for the migrating cells that are important for ocular surface regeneration.
The effect of platelet-rich fibrin on wound healing following strabismus surgery
There was only a significant difference for α-SMA related to myofibroblast activity which is important for wound remodelling which is consistent with the hypothesis that PRF facilitates wound healing as a biocatalyst.


Activation and suppression of fibroblast function
The role of the fibroblast is highlighted, some of the growth factors stimulating fibro-blast proliferation, migration and extracellular matrix production in the wound environment are discussed, and current methods of suppressing fibro Blast proliferation are reviewed.
The effect of tranilast on experimental proliferative vitreoretinopathy
Tranilast effectively inhibits the progression of PVR without showing apparent toxicity of the eye and this agent has therapeutic value for PVR.
Suramin inhibits wound healing following filtering procedures for glaucoma
In this in vivo model, suramin has been shown to be highly effective in preventing scarring and in having fewer toxic side effects than usually used antimetabolites and may suggest a new approach to the surgical treatment of glaucoma.
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The delay in fibroblast recruitment and wound contraction, the thinner scar tissue, and the increased survival of the bleb are all factors that suggest that beta irradiation may be a useful adjunct to glaucoma surgery.
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The results indicated that administration of topical medication, irrespective of type, for 3 years or more induced a significant degree of subclinical inflammation within the conjunctiva.
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A novel therapeutic approach to reducing scarring in post-natal life is suggested by using neutralising antibody to transforming growth factor-beta 1,2 to alter the growth factor profile of cutaneous wounds in adult rodents and studying the effect on scar tissue formation.
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  • Biology, Medicine
    Progress in Retinal and Eye Research
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Reversal of topical antiglaucoma medication effects on the conjunctiva.
The preoperative regimen used reversed the adverse conjunctival effect of topical medication and may be of clinical benefit in improving the success rate of trabeculectomy.
In Vitro Effect of Ascorbic Acid on the Proliferation of Bovine Scleral and Tenon's Capsule Fibroblasts
Physiological concentrations of ascorbic acid may be valuable in the pharmacological prevention of failure of glaucoma filtration surgery, however, extensive clinical investigations are needed to clarify whether topical intraoperative or postoperative as well as oral administration of as Corbenic acid inhibits fibroblast proliferation after glau coma filTration surgery.