Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model.

@article{Zhang2014ModulatingAA,
  title={Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model.},
  author={Tuo Zhang and He Wang and Qing Hua Li and Jian-kang Huang and Xiaojiang Sun},
  journal={Neuroscience},
  year={2014},
  volume={263},
  pages={130-7}
}
AIMS To explore the effects of modulating autophagy on neuroamyloidogenesis in an ischemic stroke model of cultured neuroblastoma 2a (N2a)/Amyloid precursor protein (APP)695 cells. METHODS The ischemic stroke model of N2a/APP695 cells was made by 6h oxygen-glucose deprivation/12h reperfusion (OGDR). Drug administration of 3-methyladenine (3-MA), rapamycin or dl-3-n-butylphthalide (NBP) was started at the beginning of the OGDR and lasted until the end of reperfusion, in order to explore their… CONTINUE READING