Modulating T regulatory cells in cancer: how close are we?

Abstract

Regulatory T cells (Tregs) are a specialized subset of CD4 T cells that have an indispensable role in maintaining immune homeostasis and tolerance. Although studies in mice and humans have clearly highlighted that the absence of these cells results in severe autoimmunity and inflammation, increased Treg numbers and/or function is not always beneficial. This… (More)
DOI: 10.1038/icb.2013.12

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