Modulating Notch signaling to enhance neovascularization and reperfusion in diabetic mice.

Abstract

Diabetes can diminish the responsiveness to angiogenic factors (e.g., VEGF) important for wound healing and the treatment of ischemic diseases, and this study investigated the hypothesis that this effect can be reversed by altering Notch signaling. Aortic endothelial cells (ECs) isolated from diabetic mice demonstrated reduced sprouting capability in vitro… (More)
DOI: 10.1016/j.biomaterials.2010.08.002

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