Modulating Membrane Composition Alters Free Fatty Acid Tolerance in Escherichia coli

@inproceedings{Lennen2013ModulatingMC,
  title={Modulating Membrane Composition Alters Free Fatty Acid Tolerance in Escherichia coli},
  author={Rebecca M. Lennen and Brian F Pfleger},
  booktitle={PloS one},
  year={2013}
}
Microbial synthesis of free fatty acids (FFA) is a promising strategy for converting renewable sugars to advanced biofuels and oleochemicals. Unfortunately, FFA production negatively impacts membrane integrity and cell viability in Escherichia coli, the dominant host in which FFA production has been studied. These negative effects provide a selective pressure against FFA production that could lead to genetic instability at industrial scale. In prior work, an engineered E. coli strain harboring… CONTINUE READING
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Membrane Stresses Induced by Endogenous Free Fatty Acid Overproduction in Escherichia coli

  • RM Lennen, MA Kruziki, K Kumar, RA Zinkel, KE Burnum
  • Appl Environ Microbiol
  • 2011
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