Modulating Hox gene functions during animal body patterning

@article{Pearson2005ModulatingHG,
  title={Modulating Hox gene functions during animal body patterning},
  author={Joseph C. Pearson and Derek Lemons and William McGinnis},
  journal={Nature Reviews Genetics},
  year={2005},
  volume={6},
  pages={893-904}
}
With their power to shape animal morphology, few genes have captured the imagination of biologists as the evolutionarily conserved members of the Hox clusters have done. Recent research has provided new insight into how Hox proteins cause morphological diversity at the organismal and evolutionary levels. Furthermore, an expanding collection of sequences that are directly regulated by Hox proteins provides information on the specificity of target-gene activation, which might allow the successful… Expand

Figures, Tables, and Topics from this paper

Paper Mentions

The regulation of Hox gene expression during animal development
TLDR
A diverse range of mechanisms, including nuclear dynamics, RNA processing, microRNA and translational regulation, all concur to control Hox gene outputs and it is proposed that this complex multi-tiered regulation might contribute to the robustness of Hox expression during development. Expand
Reassessing the Role of Hox Genes during Vertebrate Development and Evolution.
  • M. Mallo
  • Biology, Medicine
  • Trends in genetics : TIG
  • 2018
TLDR
These studies show that Hox genes do not control the basic layout of the vertebrate body plan but carry out region-specific patterning instructions loaded on the derivatives of axial progenitors by Hox-independent processes, broadening the understanding of both limb development and the evolution of vertebrate paired appendages. Expand
Shaping segments: Hox gene function in the genomic age
  • S. D. Hueber, I. Lohmann
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2008
TLDR
The role of Hox genes in shaping segmental morphologies along the AP axis in Drosophila is focused on, some of the conclusions drawn from analyses of large target gene sets are discussed and methods that could be used to gain a more thorough understanding of H Cox molecular function are highlighted. Expand
Function and specificity of Hox genes.
TLDR
In regulating specific targets, the Hox genes interact with members of signaling pathways and with other proteins, thus forming part of gene networks that contribute to the modification of homologous structures or to the creation of new organs. Expand
Mammalian Embryo: Hox Genes
TLDR
Modulation of Hox expression or function may be important for generating differences in structures during evolution of vertebrates. Expand
Cellular analysis of newly identified Hox downstream genes in Drosophila.
TLDR
This work has validated and functionally studied many of the newly identified downstream genes of the Hox proteins Deformed and Abdominal-B, and provides evidence that H Cox proteins regulate a diverse group of downstream genes, from transcription factors to realisators with major and minor roles during morphogenesis. Expand
Comparative analysis of Hox downstream genes in Drosophila
TLDR
This work quantitatively identified hundreds of Hox downstream genes in Drosophila by microarray analysis, and validated many of them by in situ hybridizations on loss- and gain-of-function mutants, providing a framework for the morphogenesis of the maxillary segment. Expand
Regulation of Hox activity: insights from protein motifs.
TLDR
The survey suggests that the homeodomain is part of an extended multifunctional unit coordinating DNA binding and activity regulation and highlights the need for further advances in understanding of Hox protein activity. Expand
The regulation of Hox genes by microRNAs during Drosophila development
TLDR
Hox genes encode a family of evolutionarily conserved transcription factors involved in the activation of diverse cell differentiation programs along the antero-posterior axis of animals and sheds light on the ways in which Hox gene expression can contribute to the formation of complex morphological structures. Expand
Retracted: Gene duplication and functional evolution of Hox genes in fishes.
TLDR
The authors have focused on broadly outlining the duplication of Hoxgenes in fishes and discussing how comparative genomics is elucidating the molecular changes associated with the evolution of H Cox genes expression and developmental function in the teleost fishes. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 138 REFERENCES
The Drosophila Hox Gene Deformed Sculpts Head Morphology via Direct Regulation of the Apoptosis Activator reaper
TLDR
During early Drosophila development, the Hox protein Deformed maintains the boundary between the maxillary and mandibular head lobes by activating localized apoptosis, which literally sculpts segments into distinct shapes. Expand
Crustacean appendage evolution associated with changes in Hox gene expression
TLDR
It is shown that changes in the expression pattern of the Hox genes Ubx and AbdA in different crustaceans correlate well with the modification of their anterior thoracic limbs into feeding appendages (maxillipeds). Expand
Hox protein mutation and macroevolution of the insect body plan
TLDR
It is shown that naturally selected alteration of the Ubx protein is linked to the evolutionary transition to hexapod limb pattern, a major morphological transition in metazoans. Expand
dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions
TLDR
The characterization of the novel Drosophila Hox target gene dlarp is reported, isolated from a further screen of a previously described library of genomic DNA fragments associated in vivo with Ultrabithorax proteins. Expand
Evolution of a transcriptional repression domain in an insect Hox protein
TLDR
A transcriptional repression domain is identified in the carboxy-terminal region of the Drosophila Ultrabithorax (Ubx) protein, which is highly conserved among Ubx orthologues in other insects, but is absent from Ubx in other arthropods and onychophorans. Expand
Direct integration of Hox and segmentation gene inputs during Drosophila development
TLDR
It is shown that abdominal Hox proteins work directly with two different segmentation proteins, Sloppy paired and Engrailed, to repress the Hox target gene Distalless in anterior and posterior compartments, respectively, suggesting that segmentationprotein can function as Hox cofactors and reveal a previously unanticipated use of compartments for gene regulation by Hox protein. Expand
Tgfβ signaling acts on a Hox response element to confer specificity and diversity to Hox protein function
TLDR
It is shown that the Dpp/Tgfβ signal controls Abdominal A function, and that Hox protein and signal-activated regulators converge on a wingless enhancer, conferring specificity and diversity upon Abdominals A activity. Expand
A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis.
TLDR
The C. elegans Antennapedia homolog, mab-5, sequentially programs many independent events within individual cell lineages to diversify the anteroposterior axis through fine spatiotemporal differences in expression coupled with a changing pattern of cellular response. Expand
Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia
TLDR
Using DNA microarrays to screen for genes whose expression in developing distal forelimbs and genital eminences was significantly modified in the absence of the full Hoxd gene complement supports the idea that both appendices involve similar genetic controls, both upstream and downstream of the Hox gene family. Expand
The identification of Hoxc8 target genes.
TLDR
ChIP analysis confirmed the direct interaction between the OPN promoter and Hoxc8 protein in vivo, supporting the view that OPN is a direct transcriptional target of Hox c8. Expand
...
1
2
3
4
5
...