Modulating Glypican4 suppresses tumorigenicity of embryonic stem cells while preserving self-renewal and pluripotency.

@article{Fico2012ModulatingGS,
  title={Modulating Glypican4 suppresses tumorigenicity of embryonic stem cells while preserving self-renewal and pluripotency.},
  author={Annalisa Fico and Antoine de Chevigny and Joaquim Egea and Michael R. B{\"o}sl and Harold Cremer and Flavio Maina and Rosanna Dono},
  journal={Stem cells},
  year={2012},
  volume={30 9},
  pages={
          1863-74
        }
}
Self-renewal and differentiation of stem cell depend on a dynamic interplay of cell-extrinsic and -intrinsic regulators. However, how stem cells perceive the right amount of signal and at the right time to undergo a precise developmental program remains poorly understood. The cell surface proteins Glypicans act as gatekeepers of environmental signals to modulate their perception by target cells. Here, we show that one of these, Glypican4 (Gpc4), is specifically required to maintain the self… CONTINUE READING
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