Modulating G-protein-coupled receptors: from traditional pharmacology to allosterics.

Abstract

Signal transduction is the means by which cells respond to variations in their environment. G-protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, accounting for >1% of the human genome. GPCRs respond to a wide variety of extracellular signals, including peptides, ions, amino acids, hormones, growth factors, light and odorant… (More)

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Cite this paper

@article{Gilchrist2007ModulatingGR, title={Modulating G-protein-coupled receptors: from traditional pharmacology to allosterics.}, author={Annette Gilchrist}, journal={Trends in pharmacological sciences}, year={2007}, volume={28 8}, pages={431-7} }