Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels

Abstract

Inherited cardiomyopathies are a common form of heart disease that are caused by mutations in sarcomeric proteins with beta cardiac myosin (MYH7) being one of the most frequently affected genes. Since the discovery of the first cardiomyopathy associated mutation in beta-cardiac myosin, a major goal has been to correlate the in vitro myosin motor properties… (More)
DOI: 10.3389/fphys.2016.00659

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