Modulated binding of SATB1, a matrix attachment region protein, to the AT-rich sequence flanking the major breakpoint region of BCL2.

@article{Ramakrishnan2000ModulatedBO,
  title={Modulated binding of SATB1, a matrix attachment region protein, to the AT-rich sequence flanking the major breakpoint region of BCL2.},
  author={Meera Ramakrishnan and Wenshe Liu and PATRICIA A. DICROCE and A Posner and Jianyu Zheng and Terumi Kohwi-Shigematsu and Theodore G. Krontiris},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 3},
  pages={868-77}
}
The t(14,18) chromosomal translocation that occurs in human follicular lymphoma constitutively activates the BCL2 gene and disrupts control of apoptosis. Interestingly, 70% of the t(14,18) translocations are confined to three 15-bp clusters positioned within a 150-bp region (major breakpoint region or [MBR]) in the untranslated portion of terminal exon 3. We analyzed DNA-protein interactions in the MBR, as these may play some role in targeting the translocation to this region. An 87-bp segment… CONTINUE READING

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