Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma

  title={Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma},
  author={Fengdan Ye and Dongya Jia and Mingyang Lu and Herbert Levine and Michael W. Deem},
  pages={15015 - 15026}
Abnormal metabolism is an emerging hallmark of cancer. Cancer cells utilize both aerobic glycolysis and oxidative phosphorylation (OXPHOS) for energy production and biomass synthesis. Understanding the metabolic reprogramming in cancer can help design therapies to target metabolism and thereby to improve prognosis. We have previously argued that more malignant tumors are usually characterized by a more modular expression pattern of cancer-associated genes. In this work, we analyzed the… 
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Network-based metabolic characterization of renal cell carcinoma

A comprehensive metabolic network analysis of major renal cell carcinoma (RCC) subtypes including clear cell, papillary and chromophobe by integrating transcriptomic data with the human genome-scale metabolic model to understand the coordination of metabolic pathways in cancer cells is performed.

The Prognostic Value of Metabolic Genes in Gastric Adenocarcinoma

A novel 13-gene metabolic model is constructed in this study to predict the prognosis for gastric cancer, probably reflects dysregulation in the metabolic microenvironment, in the meantime of providing metabolic treatment biomarkers, and predicting the treatment response to gastric adenocarcinoma.

Metabolic genes show excellent prognostic ability for clear cell renal cell carcinoma

A risk model (riskScore) based on 4 MGs, which could accurately predict the prognosis of patients with clear cell renal cell carcinoma is established, which may shed new light on ccRCC patients' prognosis and treatment management.

Characterization of Mitochondrial Proteome and Function in Luminal A and Basal-like Breast Cancer Subtypes Reveals Alteration in Mitochondrial Dynamics and Bioenergetics Relevant to Their Diagnosis

It is demonstrated that basal-like tumors exhibit a vicious cycle between mitochondrial fusion and fission; impaired but not completely inactive mitochondrial function; and the Warburg effect, associated with decreased oxidative phosphorylation (OXPHOS) complexes I and III.



Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation.

It is proposed that the hybrid phenotype contributes to metabolic plasticity, allowing cancer cells to adapt to various microenvironments, and design cancer therapies targeting metabolism.

The Emerging Hallmarks of Cancer Metabolism.

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis

It is demonstrated that early preneoplastic foci and nodules that progress towards hepatocellular carcinoma (HCC) are characterized both by inhibition of oxidative phosphorylation (OXPHOS) and by enhanced glucose utilization to fuel the pentose phosphate pathway (PPP).

Loss of FBP1 facilitates aggressive features of hepatocellular carcinoma cells through the Warburg effect

FBP1 appears to be a tumor suppressor in HCC, and targeting the Warburg effect using the specific inhibitor FX11 could suppress the aggressiveness of HCC cells which was mediated by loss of FBP1.

Cancer network activity associated with therapeutic response and synergism

Cancer therapeutic responses can be predicted on the basis of a systems-level analysis of molecular interactions and gene expression, which can also be exploited to predict precise synergistic drug combinations.

HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress

The data suggest that HBx plays a key role in the maintenance of redox and energy homeostasis by activating FAO, which is critical for HCC cell survival under conditions of metabolic stress and might be exploited for therapeutic benefit.

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

It is demonstrated that a subpopulation of dormant tumour cells surviving oncogene ablation (surviving cells) and responsible for tumour relapse has features of cancer stem cells and relies on oxidative phosphorylation for survival.

Hierarchy in gene expression is predictive of risk, progression, and outcome in adult acute myeloid leukemia

It is found that the hierarchy in gene expression at the time of diagnosis may be a useful biomarker in AML prognosis and the variation of the level of organization in the gene network with cancer progression is non-monotonic.

A mitochondrial switch promotes tumor metastasis.

Tumor Cells Switch to Mitochondrial Oxidative Phosphorylation under Radiation via mTOR-Mediated Hexokinase II Inhibition - A Warburg-Reversing Effect

It is reported that mTOR, a critical regulator in cell proliferation, can be relocated to mitochondria, and as a result, enhances oxidative phosphorylation and reduces glycolysis and a “waking-up” pathway for mitochondrial bioenergetics is demonstrated.