Modularity and homology: modelling of the titin type I modules and their interfaces.

@article{Amodeo2001ModularityAH,
  title={Modularity and homology: modelling of the titin type I modules and their interfaces.},
  author={Pietro Amodeo and F. Fraternali and Arthur M. Lesk and Annalisa Pastore},
  journal={Journal of molecular biology},
  year={2001},
  volume={311 2},
  pages={283-96}
}
Titin is a giant muscle protein with a highly modular architecture consisting of multiple repeats of two sequence motifs, named type I and type II. Type I motifs are homologous to members of the fibronectin type 3 (Fn3) superfamily, one of the motifs most widespread in modular proteins. Fn3 domains are thought to mediate protein-protein interactions and to act as spacers. In titin, Fn3 modules are present in two different super-repeated patterns, likely to be involved in sarcomere assembly… CONTINUE READING