Modular structure of the TIM23 preprotein translocase of mitochondria.

  title={Modular structure of the TIM23 preprotein translocase of mitochondria.},
  author={I Milisav and Fernando Gomes Moro and Walter Neupert and Michael Brunner},
  journal={The Journal of biological chemistry},
  volume={276 28},
The TIM23 complex mediates import into mitochondria of nuclear encoded preproteins with a matrix-targeting signal. It is composed of the integral membrane proteins Tim17 and Tim23 and the peripheral membrane protein Tim44, which recruits mitochondrial Hsp70 to the sites of protein import. We have analyzed the functions of these constituents using a combined genetic and biochemical approach. Depletion of either Tim17 or Tim23 led to loss of import competence of mitochondria and to a reduction in… CONTINUE READING

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