Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production.

@article{Zhou2012ModularPE,
  title={Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production.},
  author={Yongjin J Zhou and Wei Gao and Qixians Rong and Guojie Jin and Huiying Chu and Wujun Liu and Wei Yang and Zhiwei Zhu and Guohui Li and Guofeng Zhu and Luqi Huang and Zongbao K Zhao},
  journal={Journal of the American Chemical Society},
  year={2012},
  volume={134 6},
  pages={
          3234-41
        }
}
Microbial production can be advantageous over the extraction of phytoterpenoids from natural plant sources, but it remains challenging to rationally and rapidly access efficient pathway variants. Previous engineering attempts mainly focused on the mevalonic acid (MVA) or methyl-d-erythritol phosphate (MEP) pathways responsible for the generation of precursors for terpenoids biosynthesis, and potential interactions between diterpenoids synthases were unexplored. Miltiradiene, the product of the… CONTINUE READING
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