Modular organization of the brainstem noradrenaline system coordinates opposing learning states

@article{Uematsu2017ModularOO,
  title={Modular organization of the brainstem noradrenaline system coordinates opposing learning states},
  author={Akira Uematsu and Bao Zhen. Tan and Edgar A Ycu and Jessica Sulkes Cuevas and Jenny Koivumaa and F{\'e}lix Junyent and Eric J. Kremer and Ilana B. Witten and Karl Deisseroth and Joshua P. Johansen},
  journal={Nature Neuroscience},
  year={2017},
  volume={20},
  pages={1602-1611}
}
Noradrenaline modulates global brain states and diverse behaviors through what is traditionally believed to be a homogeneous cell population in the brainstem locus coeruleus (LC). However, it is unclear how LC coordinates disparate behavioral functions. We report a modular LC organization in rats, endowed with distinct neural projection patterns and coding properties for flexible specification of opposing behavioral learning states. LC projection mapping revealed functionally distinct cell… 

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