Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton

@article{Marfatia1996ModularOO,
  title={Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton},
  author={Shirin M. Marfatia and J H Morais Cabral and Li Shin Lin and Colleen Hough and Peter J. Bryant and Leslie Stolz and Athar H Chishti},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={135},
  pages={753 - 766}
}
The human homologue (hDIg) of the Drosophila discs-large tumor suppressor (DIg) is a multidomain protein consisting of a carboxyl-terminal guanylate kinase-like domain, an SH3 domain, and three slightly divergent copies of the PDZ (DHR/GLGF) domain. Here have examined the structural organization of the three PDZ domains of hDIg using a combination of protease digestion and in vitro binding measurements. Our results show that the PDZ domains are organized into two conformationally stable modules… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

Proteasome-mediated regulation of the hDlg tumour suppressor protein.

  • Journal of cell science
  • 2001
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation.

  • Molecular biology of the cell
  • 2001
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton.

  • Journal of cell science
  • 1998
VIEW 2 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 58 REFERENCES

The C

R. Hoskins, A. F. Hajnal, S. A. Harp, S. K. Kim.
  • elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins. Development (Camb.). 122:97-111.
  • 1996
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Cloning and characterization of hdlg : the human homologue of the Drosophila discs large tumor suppressor binds to protein 4 . 1

R. A. Lue, D. Branton, A. H. Chishti
  • Proc . Natl . Acad . Sci . USA .
  • 1994
VIEW 19 EXCERPTS
HIGHLY INFLUENTIAL

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1996
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL