Modular genes with metazoan-specific domains have increased tissue specificity.

@article{CohenGihon2005ModularGW,
  title={Modular genes with metazoan-specific domains have increased tissue specificity.},
  author={Inbar Cohen-Gihon and Doron Lancet and Itai Yanai},
  journal={Trends in genetics : TIG},
  year={2005},
  volume={21 4},
  pages={
          210-3
        }
}
We have systematically examined the domain composition across a comprehensive set of tissue-specific, midrange and housekeeping genes as defined by their mode of expression in 52 normal mouse tissues. We show a definite correlation between the number of domains and the degree of tissue specificity. This trend is further supported by a novel analysis involving the time of origin of each domain. Genes containing metazoan-specific domains are more prevalent in signal transduction and cell… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Similar Papers

Loading similar papers…