Modular decomposition of protein-protein interaction networks

@article{Gagneur2004ModularDO,
  title={Modular decomposition of protein-protein interaction networks},
  author={Julien Gagneur and Roland Krause and Tewis Bouwmeester and Georg Casari},
  journal={Genome Biology},
  year={2004},
  volume={5},
  pages={R57 - R57}
}
We introduce an algorithmic method, termed modular decomposition, that defines the organization of protein-interaction networks as a hierarchy of nested modules. Modular decomposition derives the logical rules of how to combine proteins into the actual functional complexes by identifying groups of proteins acting as a single unit (sub-complexes) and those that can be alternatively exchanged in a set of similar complexes. The method is applied to experimental data on the pro-inflammatory tumor… CONTINUE READING

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Functional characterization of ABC 10 alpha , an essential polypeptide shared by all three forms of eukaryotic DNAdependent

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