Modular decomposition of metabolic reaction networks based on flux analysis and pathway projection

@article{Yoon2007ModularDO,
  title={Modular decomposition of metabolic reaction networks based on flux analysis and pathway projection},
  author={Jeongah Yoon and Yaguang Si and Ryan Nolan and Kyongbum Lee},
  journal={Bioinformatics},
  year={2007},
  volume={23 18},
  pages={2433-40}
}
MOTIVATION The rational decomposition of biochemical networks into sub-structures has emerged as a useful approach to study the design of these complex systems. A biochemical network is characterized by an inhomogeneous connectivity distribution, which gives rise to several organizational features, including modularity. To what extent the connectivity-based modules reflect the functional organization of the network remains to be further explored. In this work, we examine the influence of… CONTINUE READING