Modular assembly of yeast cytochrome oxidase

  title={Modular assembly of yeast cytochrome oxidase},
  author={Gavin P. McStay and Chen Su and Alexander Tzagoloff},
  booktitle={Molecular biology of the cell},
Previous studies of yeast cytochrome oxidase (COX) biogenesis identified Cox1p, one of the three mitochondrially encoded core subunits, in two high-molecular weight complexes combined with regulatory/assembly factors essential for expression of this subunit. In the present study we use pulse-chase labeling experiments in conjunction with isolated mitochondria to identify new Cox1p intermediates and place them in an ordered pathway. Our results indicate that before its assimilation into COX… CONTINUE READING