Modular arrangement of proteins as inferred from analysis of homology.

@article{Sonnhammer1994ModularAO,
  title={Modular arrangement of proteins as inferred from analysis of homology.},
  author={Erik L. L. Sonnhammer and Daniel Kahn},
  journal={Protein science : a publication of the Protein Society},
  year={1994},
  volume={3 3},
  pages={482-92}
}
The structure of many proteins consists of a combination of discrete modules that have been shuffled during evolution. Such modules can frequently be recognized from the analysis of homology. Here we present a systematic analysis of the modular organization of all sequenced proteins. To achieve this we have developed an automatic method to identify protein domains from sequence comparisons. Homologous domains can then be clustered into consistent families. The method was applied to all 21,098… CONTINUE READING
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