Modular analysis of signal transduction networks

  title={Modular analysis of signal transduction networks},
  author={Julio Saez-Rodriguez and Andreas Kremling and Holger Conzelmann and Katja Bettenbrock and E. D. Gilles},
  journal={IEEE Control Systems},
This paper introduces compelling problems of biological systems and signaling networks to show how engineering tools can be applied to the analysis of the cellular machinery. The mechanisms that cells have developed to process information are described, and the decomposition of signalling networks into subsystems is discussed. A novel criterion for defining modules based on the absence of retroactivity is also presented, and some simple criteria for the analysis of the resulting units are… CONTINUE READING


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