Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates.

Abstract

Herein is described a new modular platform for the construction of cancer-cell-targeting drug conjugates. Tripodal boronate complexes featuring reversible covalent bonds were designed to accommodate a cytotoxic drug (bortezomib), poly(ethylene glycol) (Peg) chains, and folate targeting units. The B-complex core was assembled in one step, proved stable under… (More)
DOI: 10.1002/anie.201703492

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