Modifying tumor-associated macrophages

  title={Modifying tumor-associated macrophages},
  author={Zvi Gregory Fridlender and Steven M. Albelda},
The therapeutic success of immunotherapy requires specific alterations of the tumor microenvironment and/or the inhibition of tumor-elicited immunosuppression. Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment. We have recently shown that modulating TAMs dramatically augments the efficacy of immunotherapy. TAM-activating agents should hence be considered as an addition to immunotherapy in future clinical trials. 
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