Modifying the product pattern of Clostridium acetobutylicum

@article{Lehmann2011ModifyingTP,
  title={Modifying the product pattern of Clostridium acetobutylicum},
  author={D{\"o}rte Lehmann and Daniel H{\"o}nicke and Armin Ehrenreich and Michael Schmidt and Dirk Weuster-Botz and Hubert Bahl and Tina Luetke-Eversloh},
  journal={Applied Microbiology and Biotechnology},
  year={2011},
  volume={94},
  pages={743-754}
}
Clostridial acetone–butanol–ethanol (ABE) fermentation is a natural source for microbial n-butanol production and regained much interest in academia and industry in the past years. Due to the difficult genetic accessibility of Clostridium acetobutylicum and other solventogenic clostridia, successful metabolic engineering approaches are still rare. In this study, a set of five knock-out mutants with defects in the central fermentative metabolism were generated using the ClosTron technology… CONTINUE READING
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