Modifying the host range properties of retroviral vectors.

  title={Modifying the host range properties of retroviral vectors.},
  author={Stephen Russell and Francois Loic Cosset},
  journal={The journal of gene medicine},
  volume={1 5},
Gene therapy protocols would be greatly facilitated by the availability of targetable injectable vectors which could deliver genes in vivo to specific target cells or to specific disease sites. Efforts to develop such retroviral vectors are therefore a high priority in gene therapy research. In this review, we describe the current state of our understanding of the structure and function of the retroviral envelope glycoprotein complex. We then discuss the results of the various strategies that… CONTINUE READING

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