Modifying the epigenome as a therapeutic strategy in myelodysplasia.


The term epigenetics refers to a number of biochemical modifications of chromatin that, without altering the primary sequence of DNA, have a role in genomic regulation and in particular gene expression control. These modifications can occur at the DNA level (i.e., DNA methylation), and affect the chromatin protein scaffold (i.e., histone code modifications… (More)


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@article{GarcaManero2007ModifyingTE, title={Modifying the epigenome as a therapeutic strategy in myelodysplasia.}, author={Guillermo Garc{\'i}a-Manero}, journal={Hematology. American Society of Hematology. Education Program}, year={2007}, pages={405-11} }