Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria.

@article{Miller2009ModifyingCC,
  title={Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria.},
  author={Christopher H Miller and Shahista Nisa and Sandi G Dempsey and Cameron A. Jack and Ronan O'Toole},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 12},
  pages={5279-83}
}
In this study, application of a dual absorbance/fluorescence assay to a chemical library screen identified several previously unknown inhibitors of mycobacteria. In addition, growth conditions had a significant effect on the activity profile of the library. Some inhibitors such as Se-methylselenocysteine were detected only when screening was performed under nutrient-limited culture conditions as opposed to nutrient-rich culture conditions. We propose that multiple culture condition library… CONTINUE READING
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