Modifying Gene Expression Programs by Altering Core Promoter Chromatin Architecture

  title={Modifying Gene Expression Programs by Altering Core Promoter Chromatin Architecture},
  author={Stavros Lomvardas and Dimitris Thanos},
Transcriptional activation of the IFN-beta gene in response to virus infection requires the assembly of an enhanceosome, which instructs a recruitment program of chromatin modifiers/remodelers and general transcription factors to the promoter. This program culminates with sliding of a nucleosome blocking the core promoter to a downstream position, a prerequisite for transcriptional activation. We show that delivery of this nucleosome to the same downstream position to create an accessible IFN… CONTINUE READING


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