Modifying Gene Expression Programs by Altering Core Promoter Chromatin Architecture

@article{Lomvardas2002ModifyingGE,
  title={Modifying Gene Expression Programs by Altering Core Promoter Chromatin Architecture},
  author={Stavros Lomvardas and Dimitris Thanos},
  journal={Cell},
  year={2002},
  volume={110},
  pages={261-271}
}
Transcriptional activation of the IFN-beta gene in response to virus infection requires the assembly of an enhanceosome, which instructs a recruitment program of chromatin modifiers/remodelers and general transcription factors to the promoter. This program culminates with sliding of a nucleosome blocking the core promoter to a downstream position, a prerequisite for transcriptional activation. We show that delivery of this nucleosome to the same downstream position to create an accessible IFN… CONTINUE READING

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