Modifier genes in humans: strategies for identification

@article{Houlston1998ModifierGI,
  title={Modifier genes in humans: strategies for identification},
  author={Rs Houlston and I. P. M. Tomlinson},
  journal={European Journal of Human Genetics},
  year={1998},
  volume={6},
  pages={80-88}
}
A number of genetic disorders exhibit inter- and intra-familial variability. Understanding the factors that control the expression of disease genes should provide insight into the fundamental disease processes and will have implications for counselling patients. Different mechanisms can account for this variability, including environmental factors, genotype–phenotype correlations and imprinting. There is also evidence that, in a number of genetic diseases, gene expression is under the control… CONTINUE READING

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