Modified vaccinia virus Ankara encoding influenza virus hemagglutinin induces heterosubtypic immunity in macaques.

@article{Florek2014ModifiedVV,
  title={Modified vaccinia virus Ankara encoding influenza virus hemagglutinin induces heterosubtypic immunity in macaques.},
  author={Nicholas W. Florek and Jason T Weinfurter and Sinthujan Jegaskanda and Joseph N. Brewoo and Tim D Powell and Ginger Young and Subash C. Das and Masato Hatta and Karl W. Broman and Olav Hungnes and Susanne G Dudman and Yoshihiro Kawaoka and Stephen J Kent and Dan T. Stinchcomb and Jorge E. Osorio and Thomas C Friedrich},
  journal={Journal of virology},
  year={2014},
  volume={88 22},
  pages={13418-28}
}
UNLABELLED Current influenza virus vaccines primarily aim to induce neutralizing antibodies (NAbs). Modified vaccinia virus Ankara (MVA) is a safe and well-characterized vector for inducing both antibody and cellular immunity. We evaluated the immunogenicity and protective efficacy of MVA encoding influenza virus hemagglutinin (HA) and/or nucleoprotein (NP) in cynomolgus macaques. Animals were given 2 doses of MVA-based vaccines 4 weeks apart and were challenged with a 2009 pandemic H1N1… CONTINUE READING