Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication.

@article{Lynch2009ModifiedVV,
  title={Modified vaccinia virus Ankara can activate NF-kappaB transcription factors through a double-stranded RNA-activated protein kinase (PKR)-dependent pathway during the early phase of virus replication.},
  author={Heather E. Lynch and Caroline A. Ray and Katrina L Oie and Justin J. Pollara and Ian T D Petty and Anthony J Sadler and Bryan Raymond George Williams and David J. Pickup},
  journal={Virology},
  year={2009},
  volume={391 2},
  pages={177-86}
}
Modified vaccinia virus Ankara (MVA), which is a promising replication-defective vaccine vector, is unusual among the orthopoxviruses in activating NF-kappaB transcription factors in cells of several types. In human embryonic kidney (HEK 293T) cells, the MVA-induced depletion of IkappaBalpha required to activate NF-kappaB is inhibited by UV-inactivation of the virus, and begins before viral DNA replication. In HEK 293T, CHO, or RK13 cells, expression of the cowpox virus CP77 early gene, or the… CONTINUE READING