Modified polyvinylalcohol for encapsulation of all-trans-retinoic acid in polymeric micelles.

@article{Zuccari2005ModifiedPF,
  title={Modified polyvinylalcohol for encapsulation of all-trans-retinoic acid in polymeric micelles.},
  author={Guendalina Zuccari and Roberta Carosio and Adamo Fini and Paolo Giuseppe Montaldo and Isabella Orienti},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2005},
  volume={103 2},
  pages={369-80}
}
All-trans-retinoic acid (ATRA) is now included in many antitumor therapeutic schemes for the treatment of acute promyelocytic leukaemia, Kaposi's sarcoma, head and neck squamous cell carcinoma, ovarian carcinoma, bladder cancer and neuroblastoma. Unfortunately its poor aqueous solubility hampers its parenteral formulation. To date, there is no parenteral formulation of ATRA commercially available and oral administration of ATRA is associated with progressively diminishing ATRA levels in plasma… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…