Modified polyriboinosinic-polyribocytidylic acid complex: sustained interferonemia and its physiological associates in humans.

@article{Champney1979ModifiedPA,
  title={Modified polyriboinosinic-polyribocytidylic acid complex: sustained interferonemia and its physiological associates in humans.},
  author={K J Champney and Donald P. Levine and Hilton B. Levy and A. Martin Lerner},
  journal={Infection and immunity},
  year={1979},
  volume={25 3},
  pages={831-7}
}
Fourteen patients with severe viral illnesses were given intravenous infusions of a modified interferon inducer, polyriboinosinic-polyribocytidylic acid-poly-L-lysine complexed with carboxymethylcellulose [poly)I:C.LC)], during a phase 1 clinical trial. The first eight patients received 0.15 to 0.30 mg of poly(I:C.LC) per kg of body weight daily for 5 consecutive days, and another received two courses separated by 1 week. A second group of five patients was given single intravenous infusions of… CONTINUE READING

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