Modified nanoprecipitation method to fabricate DNA-loaded PLGA nanoparticles.

  title={Modified nanoprecipitation method to fabricate DNA-loaded PLGA nanoparticles.},
  author={Xiuming Niu and Weiwei Zou and Chun-xi Liu and Na Zhang and Chunhua Fu},
  journal={Drug development and industrial pharmacy},
  volume={35 11},
OBJECTIVE The objective of this study was to formulate DNA-loaded poly(d,l-lactide-co-glycotide) (PLGA) nanoparticles by a modified nanoprecipitation method. METHODS DNA-loaded PLGA nanoparticles were prepared by the modified nanoprecipitation method and the double emulsion/solvent evaporation method. The characterizations of DNA-loaded nanoparticles such as entrapment efficiency, morphology, particle size, zeta potential, structural integrity of the loaded DNA, and stability of the loaded… CONTINUE READING