Modified merozoite surface protein-1 peptides with short alpha helical regions are associated with inducing protection against malaria.

@article{Torres2003ModifiedMS,
  title={Modified merozoite surface protein-1 peptides with short alpha helical regions are associated with inducing protection against malaria.},
  author={Mary Helena Torres and Luz Mary Salazar and Magnolia Vanegas and F. J. Laso Guzm{\'a}n and Ra{\'u}l A. Ponce Rodriguez and Yolanda Silva and J. Lugo Rosas and Manuel Elkin Patarroyo},
  journal={European journal of biochemistry},
  year={2003},
  volume={270 19},
  pages={3946-52}
}
The merozoite surface protein-1 represents a prime candidate for development of a malaria vaccine. Merozoite surface protein-1 has been shown to demonstrate high-activity peptide binding to human red blood cells. One of the high-activity binding peptides, named 5501, located in the N-terminus (amino acid sequence MLNISQHQCVKKQCPQNS) of the 19-kDa molecular mass fragment of merozoite surface protein-1, is conserved, nonimmunogenic and nonprotective. Its critical binding residues were identified… CONTINUE READING

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