Modified ligand binding to the naturally occurring Cys-124 variant of the human serotonin 5-HT1B receptor.

@article{Brss1999ModifiedLB,
  title={Modified ligand binding to the naturally occurring Cys-124 variant of the human serotonin 5-HT1B receptor.},
  author={Michael Br{\"u}ss and Heinz B{\"o}nisch and Michael B{\"u}hlen and Markus M. N{\"o}then and P. Propping and Manfred G{\"o}thert},
  journal={Pharmacogenetics},
  year={1999},
  volume={9 1},
  pages={95-102}
}
A substitution of phenylalanine by cysteine in position 124 is the only known naturally occurring variant of the human 5-HT1B (h5-HT1B) receptor. The present study was designed to evaluate the potential influence of the Cys-124 variant on pharmacological properties of the receptor and to test for an involvement of the mutation in the genetic predisposition to schizophrenia or bipolar affective disorder. Binding of [3H]5-carboxamidotryptamine ([3H]5-CT) and its competition with serotonin… CONTINUE READING
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