Modified lactone/carboxylate salt equilibria in vivo by liposomal delivery of 9-nitro-camptothecin.


The lactone stability of camptothecins is critical for their anticancer activity. A stable liposomal 9-nitro-camptothecin formulation was developed to circumvent the drawbacks of low aqueous solubility and lactone instability and to provide sustained release of the agent in blood circulation. The potential merits of the formulation were demonstrated by its… (More)