Modified human glucagon-like peptide-1 (GLP-1) produced in E. coli has a long-acting therapeutic effect in type 2 diabetic mice

Abstract

Glucagon-like peptide 1 (GLP-1) is a very potent insulinotropic hormone secreted into the blood stream after eating. Thus, it has potential to be used in therapeutic treatment of diabetes. The half-life of GLP-1, however, is very short due to its rapid cleavage by dipeptidyl peptidase IV (DPP-IV). This presents a great challenge if it is to be used as a… (More)
DOI: 10.1371/journal.pone.0181939

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@inproceedings{Xu2017ModifiedHG, title={Modified human glucagon-like peptide-1 (GLP-1) produced in E. coli has a long-acting therapeutic effect in type 2 diabetic mice}, author={Fangfang Xu and Kevin Yueju Wang and Nan Wang and Gangqiang Li and Dehu Liu}, booktitle={PloS one}, year={2017} }