Modified apple polysaccharides suppress the migration and invasion of colorectal cancer cells induced by lipopolysaccharide.

@article{Zhang2013ModifiedAP,
  title={Modified apple polysaccharides suppress the migration and invasion of colorectal cancer cells induced by lipopolysaccharide.},
  author={Dian Zhang and Yuhua Li and Man Mi and Feng-Liang Jiang and Zheng-gang Yue and Yang Sun and Lei Fan and J. F. Meng and Xin Zhang and Li Liu and Qi-bing Mei},
  journal={Nutrition research},
  year={2013},
  volume={33 10},
  pages={839-48}
}
Metastasis is the major cause of death in colorectal cancer (CRC). In colitis-associated carcinogenesis, the activation of nuclear factor-κB (NF-κB) occurs via lipopolysaccharide (LPS) binding to the toll-like receptor 4 (TLR4). The LPS/TLR4/NF-κB pathway contributes to the development and metastasis of colitis-associated colon cancer. In the present study, we hypothesized that an extracted modified Fuji apple polysaccharide (MAP) would alter the LPS/TLR4/NF-κB pathway. Thus, we evaluated the… CONTINUE READING