Modified amyloid variants in pathological subgroups of β‐amyloidosis

@inproceedings{Gerth2018ModifiedAV,
  title={Modified amyloid variants in pathological subgroups of β‐amyloidosis},
  author={Janina Gerth and Sathish Kumar and Ajeet Rijal Upadhaya and Estifanos Ghebremedhin and Christine A. F. von Arnim and Dietmar Rudolf Thal and Jochen Walter},
  booktitle={Annals of clinical and translational neurology},
  year={2018}
}
Objective Amyloid β (Aβ) depositions in plaques and cerebral amyloid angiopathy (CAA) represent common features of Alzheimer's disease (AD). Sequential deposition of post-translationally modified Aβ in plaques characterizes distinct biochemical stages of Aβ maturation. However, the molecular composition of vascular Aβ deposits in CAA and its relation to plaques remain enigmatic. Methods Vascular and parenchymal deposits were immunohistochemically analyzed for pyroglutaminated and… CONTINUE READING

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